Tec29 controls actin remodeling and endoreplication during the invagination of the Drosophila embryonic salivary glands

SMC Author

Vidya Chandrasekaran

SMC Affiliated Work

1

Author Role

co-author

Status

Faculty

School

School of Science

Department

Biology

Document Type

Article

Publication Date

12-2005

Publication / Conference / Sponsorship

Development

Description/Abstract

pithelial invagination is necessary for formation of many tubular organs, one of which is the Drosophila embryonic salivary gland. We show that actin reorganization and control of endocycle entry are crucial for normal invagination of the salivary placodes. Embryos mutant for Tec29, the Drosophila Tec family tyrosine kinase, showed delayed invagination of the salivary placodes. This invagination delay was partly the result of an accumulation of G-actin in the salivary placodes, indicating that Tec29 is necessary for maintaining the equilibrium between G- and F-actin during invagination of the salivary placodes. Furthermore, normal invagination of the salivary placodes appears to require the proper timing of the endocycle in these cells; Tec29 must delay DNA endoreplication in the salivary placode cells until they have invaginated into the embryo. Taken together, these results show that Tec29 regulates both the actin cytoskeleton and the cell cycle to facilitate the morphogenesis of the embryonic salivary glands. We suggest that apical constriction of the actin cytoskeleton may provide a temporal cue ensuring that endoreplication does not begin until the cells have finished invagination.

DOI

10.1242/dev.01926

Volume

132

First Page

3515

Last Page

3524

Disciplines

Biology | Life Sciences

Original Citation

Chandrasekaran V. and Beckendorf S. K.: Tec29 controls actin remodeling and endoreplication during the invagination of the Drosophila embryonic salivary glands. Development, 132: 3515-24, 2005. 10.1242/dev.01926

Link to Full Text

Share

COinS