Evolutionary History of the Proviruses HERV-K 113 and HERV-K 115

SMC Author

Keith Garrison

SMC Affiliated Work

1

Status

Faculty

School

School of Science

Department

Biology

Document Type

Article

Publication Date

9-15-2014

Publication / Conference / Sponsorship

eLS

Publisher/Venue

John Wiley & Sons Ltd: Chichester

Description/Abstract

Human endogenous retroviruses are found throughout the genome, and most insertions predate human divergence from other primates. A small number are unique to humans and unfixed in the human genome. Much scientific interest has centered on the human endogenous retroviruses (HERV)-K113 and HERV-K115 insertions. The evolutionary history of these two endogenous proviruses is complex, and the estimates of both of their insertion times have recently been revised. HERV-K113 inserted into the genome sometime between 0.8 and 1.3 million years ago (Ma), while HERV-K115 was inserted into the genome sometime between 1.1 and 1.9 Ma. Both insertions occurred during a time when Homo erectus is believed to have been the dominant hominin species.

Keywords

endogenous retrovirus, HERV-K113, HERV-K115, hominin

Scholarly

yes

DOI

10.1002/9780470015902.a0022876

Disciplines

Biology

Original Citation

Garrison, Keith. Evolutionary History of the Proviruses HERV-K 113 and HERV-K 115 (2014). eLS. John Wiley & Sons Ltd: Chichester. 10.1002/9780470015902.a0022876 [article].

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